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Observational experiments have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-similar mortality when compared with utilization of opioid analgesics by itself.
Tend not to abruptly discontinue OXYCONTIN in patients who might be bodily dependent on opioids. Rapid discontinuation of opioid analgesics in sufferers who're physically dependent on opioids has resulted in serious withdrawal signs and symptoms, uncontrolled pain, and suicide.
The concomitant use of OXYCONTIN and CYP3A4 inducers can minimize the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY], causing reduced efficacy or onset of a withdrawal syndrome in clients who may have designed Bodily dependence to oxycodone [see WARNINGS AND PRECAUTIONS].
If you employ opioid drugs such as oxycodone when you are Expecting, your infant could develop into dependent on the drug. This can result in life-threatening withdrawal signs or symptoms in the infant after it is born. Toddlers born depending on opioids may need health-related treatment for many months.
Facts from a pharmacokinetic analyze involving thirteen individuals with mild to serious renal dysfunction (creatinine clearance Individual Information and facts for Oxycontin
It's possible you'll see an vacant pill shell as part of your stool. This is often harmless because The body has now absorbed the medicine.
Drug interactions may well alter how your prescription drugs perform or boost your hazard for severe Unwanted side effects. This document isn't going to include all achievable drug interactions.
Before you begin using this medication, question your medical doctor or pharmacist if you ought to prevent or change the way you make use of your other opioid medication(s).
When discontinuing OXYCONTIN, little by little taper the dosage using a client-precise system that considers the following: the dose of OXYCONTIN the individual has long been getting, the duration of treatment, as well as Bodily and psychological attributes of your client. To improve the chance of An effective taper and reduce withdrawal indications, it is vital the opioid tapering program is agreed upon via the client.
Accidental ingestion of even one particular dose of OXYCONTIN, Specially by little ones, may result in respiratory despair and Loss of life as a result of an overdose of oxycodone.
Consider prescribing naloxone In case check here the affected individual has family users (like little ones) or other close contacts in danger for get more info accidental ingestion or overdose.
Consider OxyContin particularly as directed by your medical professional. Do not just take a lot more than prescribed unless suggested to take action by your doctor. The successful dosage for discomfort aid varies substantially from Individual to individual.
You might have respiratory issues or withdrawal indicators if you start or stop having selected other medicines. Notify your physician if Additionally you use an antibiotic, antifungal medication, coronary heart or hypertension medication, seizure medication, or medicine to take care of HIV or hepatitis C.
Opioids are sought for nonmedical use and therefore are matter to diversion from respectable prescribed use. Take into consideration these pitfalls when prescribing or dispensing OXYCONTIN. Procedures to reduce these risks consist of prescribing check here the drug within the smallest appropriate amount and advising the patient on thorough storage from the drug during the study course of treatment method and the proper disposal of unused drug.